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Tables of the number of patients required in clinical trials using the logrank test
Author(s) -
Freedman L. S.
Publication year - 1982
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.4780010204
Subject(s) - log rank test , clinical trial , statistics , test (biology) , rank (graph theory) , computer science , medicine , survival analysis , mathematics , combinatorics , paleontology , biology
The logrank test is commonly used in the analysis of clinical trials in chronic diseases such as cancer. Existing tables for the number of patients required in such trials are based on the direct comparison of two proportions. This paper presents tables of numbers required in clinical trials using the logrank test and describes their use. The numbers required are considerably smaller than those in existing tables when the event‐free proportions are small, but otherwise comparable.