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A note on the power prior
Author(s) -
Neuenschwander Beat,
Branson Michael,
Spiegelhalter David J.
Publication year - 2009
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.3722
Subject(s) - econometrics , discounting , power analysis , power (physics) , chen , maximum likelihood , statistics , computer science , mathematics , economics , algorithm , paleontology , physics , finance , quantum mechanics , biology , cryptography
The power prior by Ibrahim and Chen ( Statist. Sci. 2000; 15 :46–60) is one of several methods to incorporate historical data in the analysis of a clinical trial. The power prior raises the likelihood of the historical data to the power parameter a 0 which quantifies the discounting of the historical data due to heterogeneity between trials. It is shown that the standard method of estimating the power parameter from the historical and current data is inappropriate, and we therefore suggest to use a modified power prior approach or to consider alternative methods instead. Copyright © 2009 John Wiley & Sons, Ltd.