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A competing risks analysis of bloodstream infection after stem‐cell transplantation using subdistribution hazards and cause‐specific hazards
Author(s) -
Beyersmann Jan,
Dettenkofer Markus,
Bertz Hartmut,
Schumacher Martin
Publication year - 2007
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.3006
Subject(s) - neutropenia , medicine , cumulative incidence , transplantation , proportional hazards model , incidence (geometry) , intensive care medicine , chemotherapy , physics , optics
After peripheral blood stem‐cell transplantation, patients treated for severe haematologic diseases enter a critical phase (neutropenia). Analysis of bloodstream infection during neutropenia has to account for competing risks. Separate Cox analyses of all cause‐specific hazards are the standardtechnique of choice, but are hard to interpret when the overall effects of covariates on the cumulative incidence function (CIF) are of interest. Proportional subdistribution hazards modelling of the subdistribution of the CIF is establishing itself as an interpretation‐friendly alternative. We apply both methods and discuss their relative merits. Copyright © 2007 John Wiley & Sons, Ltd.