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Cluster without fluster: The effect of correlated outcomes on inference in randomized clinical trials
Author(s) -
Proschan Michael,
Follmann Dean
Publication year - 2007
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.2977
Subject(s) - randomization , type i and type ii errors , resampling , statistics , inference , randomized controlled trial , statistic , correlation , null hypothesis , test statistic , restricted randomization , mathematics , causal inference , statistical hypothesis testing , intuition , clinical trial , permutation (music) , econometrics , computer science , medicine , psychology , artificial intelligence , geometry , cognitive science , physics , acoustics
Inference for randomized clinical trials is generally based on the assumption that outcomes are independently and identically distributed under the null hypothesis. In some trials, particularly in infectious disease, outcomes may be correlated. This may be known in advance (e.g. allowing randomization of family members) or completely unplanned (e.g. sexual sharing among randomized participants). There is particular concern when the form of the correlation is essentially unknowable, in which case we cannot take advantage of the correlation to construct a more efficient test. Instead, we can only investigate the impact of potential correlation on the independent‐samples test statistic. Randomization tends to balance out treatment and control assignments within clusters, so it is logical that performance of tests averaged over all possible randomization assignments would be essentially unaffected by arbitrary correlation. We confirm this intuition by showing that a permutation test controls the type 1 error rate in a certain averagesense whenever the clustering is independent of treatment assignment. It is nonetheless possible to obtain a ‘bad’ randomization such that members of a cluster tend to be assigned to the same treatment. Conditioned on such a bad randomization, the type 1 error rate is increased. Published in 2007 by John Wiley & Sons, Ltd.