Global tests in the additive hazards regression model | Zendy

Gandy Axel | Zendy; Therneau Terry M. | Zendy; Aalen Odd O. | Zendy

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Global tests in the additive hazards regression model

Author(s) -

Gandy Axel,

Therneau Terry M.,

Aalen Odd O.

Publication year - 2007

Publication title -

statistics in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.996

H-Index - 183

eISSN - 1097-0258

pISSN - 0277-6715

DOI - 10.1002/sim.2972

Subject(s) - covariate , statistics , test statistic , proportional hazards model , test (biology) , estimator , econometrics , statistic , post hoc , mathematics , statistical hypothesis testing , medicine , paleontology , biology

In this article, we discuss testing for the effect of several covariates in the additive hazards regression model. Bhattacharyya and Klein ( Statist. Med . 2005; 24 (14):2235–2240) note that an ad hoc weight function suggested by Aalen ( Statist. Med . 1989; 8 :907–925) is inconsistent when used as a global test for comparing groups since the test statistic depends on which group is used as the baseline group. We will suggest a simple alternative test that does not exhibit this problem. This test is a natural extension of the logrank test. We shall also discuss an alternative covariance estimator. The tests are applied to a data set and a simulation study is performed. Copyright © 2007 John Wiley & Sons, Ltd.

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