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Bayesians in clinical trials: Asleep at the switch
Author(s) -
Moyé Lemuel A.
Publication year - 2007
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.2928
Subject(s) - biostatistics , frequentist inference , bayes' theorem , bayesian probability , perspective (graphical) , econometrics , bayes factor , computer science , psychology , artificial intelligence , bayesian inference , medicine , economics , epidemiology
The refreshing Bayes perspective has much to offer biostatistics. Yet, from its 225‐year‐old roots sprung difficulties that blocked its growth at the beginning of the 20th century. Computational obstacles in concert with an inability to identify the best indifferent prior revealed a weakness on which frequentists capitalized. It took Bayesians 40 years to recover, allowing the infant field of biostatistics to fall firmly in the hands of the frequentists. Recent disillusionment with the frequentist perspective, and its hegemony of p ‐values, has produced a second opportunity for the Bayesian philosophy to make solid contributions to clinical trials. However, difficulty with the applicability of the likelihood principle, problems with prevalent prior ‘disinformation’ in clinical medicine, in concert with the complexity of truly representative loss functions threaten again to thwart the Bayesian march into biostatistics. Seven suggestions are offered to the Bayesians to help them adapt to the rigors of clinical research. Copyright © 2007 John Wiley & Sons, Ltd.