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A covariate adjusted two‐stage allocation design for binary responses in randomized clinical trials
Author(s) -
Bandyopadhyay Uttam,
Biswas Atanu,
Bhattacharya Rahul
Publication year - 2007
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.2869
Subject(s) - covariate , statistics , stage (stratigraphy) , binary number , randomized controlled trial , computer science , mathematics , econometrics , medicine , biology , arithmetic , paleontology
In the present work, we develop a two‐stage allocation rule for binary response using the log‐odds ratio within the Bayesian framework allowing the current allocation to depend on the covariate value of the current subject. We study, both numerically and theoretically, several exact and limiting properties of this design. The applicability of the proposed methodology is illustrated by using some data set. We compare this rule with some of the existing rules by computing various performance measures. Copyright © 2007 John Wiley & Sons, Ltd.