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Estimating a survival curve with unlinked entry and failure times
Author(s) -
Wu Yujun,
Shih Weichung J.,
Moore Dirk F.
Publication year - 2007
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.2819
Subject(s) - statistics , survival analysis , econometrics , computer science , mathematics
In monitoring a clinical trial or other observational study with a survival endpoint, sometimes the numbers of patients entering and dying at each time point are presented, but the connections between them are kept confidential. Hence, the exact time to failure or censoring for each individual is missing. We refer to such a study monitoring table with missing pairing information between the entry and death times as a ‘broken’ survival data set. In this paper we study the problem of estimating the survival distribution from a broken survival data set. We have developed two methods, likelihood‐based estimation and self‐consistency estimation, to estimate the survival curve parametrically and empirically, respectively. We use simulations to study the properties of these methods, and illustrate them with data from the STELLAR‐3 trial. Copyright © 2007 John Wiley & Sons, Ltd.