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A 25‐year review of sequential methodology in clinical studies
Author(s) -
Todd Susan
Publication year - 2006
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.2763
Subject(s) - subject (documents) , clinical trial , computer science , management science , operations research , data science , medical physics , medicine , library science , mathematics , pathology , engineering
This paper explores the theoretical developments and subsequent uptake of sequential methodology in clinical studies in the 25 years since Statistics in Medicine was launched. The review examines the contributions which have been made to all four phases into which clinical trials are traditionally classified and highlights major statistical advancements, together with assessing application of the techniques. The vast majority of work has been in the setting of phase III clinical trials and so emphasis will be placed here. Finally, comments are given indicating how the subject area may develop in the future. Copyright © 2006 John Wiley & Sons, Ltd.