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Optimal designs for radiation retention with Poisson correlated response
Author(s) -
LópezFidalgo J.,
Villarroel J.
Publication year - 2006
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.2654
Subject(s) - poisson distribution , poisson regression , statistics , mathematics , conditional probability distribution , medicine , population , environmental health
In this paper we describe a non‐linear model with correlated observations which accounts for the elimination rate of radiation in the lung of individuals who have been exposed to an accidental intake at some time. The response is then modelled as a conditional Poisson distribution. When the leak is moderate or the size of the particles is large a theoretical justification of this assumption is given and D ‐optimal designs are computed. Copyright © 2006 John Wiley & Sons, Ltd.