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Adaptive biased‐coin designs for skewing the allocation proportion in clinical trials with normal responses
Author(s) -
Atkinson A. C.,
Biswas A.
Publication year - 2005
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.2124
Subject(s) - adaptive design , inference , computer science , affect (linguistics) , statistics , econometrics , clinical trial , mathematical optimization , mathematics , artificial intelligence , psychology , bioinformatics , biology , communication
Response adaptive designs are used in phase III clinical trial for skewing the allocation pattern towards the better treatments. We use optimum design theory to derive adaptive designs when the responses are normally distributed. The performance of the designs is studied with respect to the loss and the proportion of allocation to different treatments. The adaptive design does not affect inference. Copyright © 2005 John Wiley & Sons, Ltd.