Premium
Sample size formula for proportional hazards modelling of competing risks
Author(s) -
Latouche Aurélien,
Porcher Raphaël,
Chevret Sylvie
Publication year - 2004
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.1915
Subject(s) - covariate , statistics , sample size determination , proportional hazards model , hazard , econometrics , mathematics , chemistry , organic chemistry
To test the effect of a therapeutic or prognostic factor on the occurrence of a particular cause of failure in the presence of other causes, the interest has shifted in some studies from the modelling of the cause‐specific hazard to that of the subdistribution hazard. We present approximate sample size formulas for the proportional hazards modelling of competing risk subdistribution, considering either independent or correlated covariates. The validity of these approximate formulas is investigated through numerical simulations. Two illustrations are provided, a randomized clinical trial, and a prospective prognostic study. Copyright © 2004 John Wiley & Sons, Ltd.