Strength of accumulating evidence and data monitoring committee decision making | Zendy

George Stephen L. | Zendy; Freidlin Boris | Zendy; Korn Edward L. | Zendy

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Strength of accumulating evidence and data monitoring committee decision making

Author(s) -

George Stephen L.,

Freidlin Boris,

Korn Edward L.

Publication year - 2004

Publication title -

statistics in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.996

H-Index - 183

eISSN - 1097-0258

pISSN - 0277-6715

DOI - 10.1002/sim.1859

Subject(s) - data monitoring committee , clinical trial , computer science , clinical decision making , component (thermodynamics) , operations research , psychology , medicine , intensive care medicine , engineering , pathology , physics , thermodynamics

The data monitoring committee (DMC) is a vital component of a randomized clinical trial. Its responsibilities include stopping the trial early for extreme results. The decision to stop the trial must be based on a careful synthesis of statistical methodology and clinical judgment. It is critical to ensure the validity of this complex process. In this paper we present results of a survey of 21 DMC members conducted to investigate how they evaluate accumulating evidence. The results indicate that some DMC members may be over‐interpreting developing trends in the data. Copyright © 2004 John Wiley & Sons, Ltd.

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