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Local influence analysis when interfacing toxicokinetic and proportional hazard models
Author(s) -
Sartori Nicola,
Thomaseth Karl,
Salvan Alberto
Publication year - 2004
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.1823
Subject(s) - context (archaeology) , toxicokinetics , hazard , proportional hazards model , statistics , econometrics , hazard ratio , mathematics , medicine , confidence interval , chemistry , pharmacokinetics , biology , paleontology , organic chemistry
We present a local influence analysis to assigned model quantities in the context of a dose–response analysis of cancer mortality in relation to estimated absorbed dose of dioxin. The risk estimation is performed using dioxin dose as a time‐dependent explanatory variable in a proportional hazard model. The dioxin dose is computed using a toxicokinetic model, which depends on some factors, such as assigned constants and estimated parameters. We present a local influence analysis to assess the effects on final results of minor perturbations of toxicokinetic model factors. In the present context, there is no evidence of local influence in risk estimates. It is however possible to identify which factors are more influential. Copyright © 2004 John Wiley & Sons, Ltd.