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Two macroscopic and microscopic brain imaging studies of human hippocampus in early Alzheimer's disease and schizophrenia research
Author(s) -
Lange Nicholas,
Lake Stephen,
Sperling Reisa,
Brown John,
Routledge Carol,
Albert Marilyn,
Heckers Stephan
Publication year - 2004
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.1720
Subject(s) - neuroscience , schizophrenia (object oriented programming) , hippocampal formation , hippocampus , human brain , functional magnetic resonance imaging , disease , brain structure and function , psychology , alzheimer's disease , neuroimaging , medicine , psychiatry , pathology
Among the many diseases that affect the hippocampus, a small yet highly important brain region responsible for memory and identity, Alzheimer's disease and schizophrenia are among the most devastating. We describe a two‐stage, region‐of‐interest based linear mixed model approach to the analysis of a longitudinal functional magnetic resonance (FMRI) study of human memory function under several drug challenges. We then describe a Monte Carlo approach to testing members of nested hierarchies of linear models in a stereological study of different types and locations of human hippocampal neurons. Last, we attempt to draw the attention of the biostatistical community interested in imaging neuroscience to the intriguing complexities of human hippocampal research in early Alzheimer's disease, schizophrenia and other brain diseases via brain imaging methods. Copyright © 2004 John Wiley & Sons, Ltd.