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Population pharmacokinetics/pharmacodynamics relationships of an anticancer drug
Author(s) -
Ané Cécile,
Concordet Didier
Publication year - 2003
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.1448
Subject(s) - pharmacodynamics , pharmacokinetics , drug , pharmacology , toxicity , regimen , population , medicine , environmental health
This paper proposes a method for studying the toxicity of an anticancer drug with a delayed effect. The goal is to predict a dosage regimen with controlled toxicity. To this end, a semi‐physiological model is used. A limit of toxicity is demonstrated, which is intrinsic to the model. It reduces the effect of high drug concentrations. This limit explains the mixed behaviour of the drug: time‐dependence and concentration‐dependence, according to the dose actually administered. A population analysis is performed to estimate the parameters of the model, and to predict a safe dosage regimen. Copyright © 2003 John Wiley & Sons, Ltd.