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Confidence intervals for the 50 per cent response dose
Author(s) -
Faraggi D.,
Izikson P.,
Reiser B.
Publication year - 2003
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.1368
Subject(s) - confidence interval , confidence distribution , robust confidence intervals , statistics , cdf based nonparametric confidence interval , mathematics , confidence region , coverage probability , credible interval , medicine
Confidence intervals for the 50 per cent response dose are usually computed using either the Delta method or Fieller's procedure. Recently, confidence intervals computed by inverting the asymptotic likelihood ratio test have also been recommended. There is some controversy as to which of these methods should be used. By means of an extensive simulation study we examine these methods as well as confidence intervals obtained by the approximate bootstrap confidence (ABC) procedure and an adjusted form of the likelihood ratio based confidence intervals. Copyright © 2003 John Wiley & Sons, Ltd.