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Dealing with competing risks: testing covariates and calculating sample size
Author(s) -
Pintilie Melania
Publication year - 2002
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.1271
Subject(s) - covariate , statistics , econometrics , proportional hazards model , event (particle physics) , sample size determination , hazard , hazard ratio , mathematics , computer science , confidence interval , organic chemistry , quantum mechanics , physics , chemistry
Abstract It is universally agreed that Kaplan–Meier estimates overestimate the probability of the event of interest in the presence of competing risks. Kalbfleisch and Prentice recommend using the cumulative incidence as an estimate of the probability of an event of interest. However, there is no consensus on how to test the effect of a covariate in the presence of competing risks. Using simulations, this paper illustrates that the Cox proportional hazards model gives valid results when employed in testing the effect of a covariate on the hazard rate and when estimating the hazard ratio. A method to calculate the sample size for testing the effect of a covariate on outcome in the presence of competing risks is also provided. Copyright © 2002 John Wiley & Sons, Ltd.