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The origin of DNA replication and Fieller's problem
Author(s) -
Truong Young K.,
Scott Rona S.,
Vos JeanMichel H.
Publication year - 2002
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.1240
Subject(s) - replication (statistics) , dna replication , confidence interval , locus (genetics) , origin of replication , dna , statistics , biology , computer science , genetics , mathematics , gene
The paper considers the statistical problem of estimating the origin of DNA replication within the human ribosomal DNA (rDNA) locus and the issue of assessing the standard error of the estimate. Based on mapping the cumulative replication index (CRI), two different modelling schemes are suggested and investigated. The statistical problem of constructing a confidence interval for the origin of DNA replication is related to Fieller's problem of obtaining a confidence interval for the ratio of two normal means. Standard normal theory, the delta and bootstrap methods are used to estimate the standard error of the estimate of the origin of DNA replication, as well as the variation of the replication rate. Copyright © 2002 John Wiley & Sons, Ltd.