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Network meta‐analysis for indirect treatment comparisons
Author(s) -
Lumley Thomas
Publication year - 2002
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.1201
Subject(s) - meta analysis , randomized controlled trial , statistics , estimation , computer science , econometrics , myocardial infarction , simple (philosophy) , medicine , mathematics , economics , management , philosophy , epistemology
I present methods for assessing the relative effectiveness of two treatments when they have not been compared directly in a randomized trial but have each been compared to other treatments. These network meta‐analysis techniques allow estimation of both heterogeneity in the effect of any given treatment and inconsistency (‘incoherence’) in the evidence from different pairs of treatments. A simple estimation procedure using linear mixed models is given and used in a meta‐analysis of treatments for acute myocardial infarction. Copyright © 2002 John Wiley & Sons, Ltd.