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Current and future challenges in the design and analysis of cluster randomization trials
Author(s) -
Klar Neil,
Donner Allan
Publication year - 2001
Publication title -
statistics in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.996
H-Index - 183
eISSN - 1097-0258
pISSN - 0277-6715
DOI - 10.1002/sim.1115
Subject(s) - randomization , cluster (spacecraft) , cluster randomised controlled trial , restricted randomization , psychological intervention , randomized controlled trial , research design , computer science , medicine , statistics , mathematics , psychiatry , surgery , programming language
Randomized trials in which the unit of randomization is a community, worksite, school or family are becoming widely used in the evaluation of life‐style interventions for the prevention of disease. The increasing interest in adopting a cluster randomization design is being matched by rapid methodological developments. In this paper we describe several of these developments. Brief mention is also made of issues related to economic analysis and to the planning and conduct of meta‐analyses for cluster randomization trials. Recommendations for reporting are also discussed. Copyright © 2001 John Wiley & Sons, Ltd.