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Stable aqueous dispersion of magnetic iron oxide core–shell nanoparticles prepared by biocompatible maleate polymers
Author(s) -
Fathi Marziyeh,
Entezami Ali Akbar
Publication year - 2014
Publication title -
surface and interface analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.52
H-Index - 90
eISSN - 1096-9918
pISSN - 0142-2421
DOI - 10.1002/sia.5362
Subject(s) - nanoparticle , materials science , polymer , chemical engineering , magnetic nanoparticles , aqueous solution , superparamagnetism , iron oxide nanoparticles , ethylene glycol , maleic anhydride , fourier transform infrared spectroscopy , polymer chemistry , dispersion stability , monomer , dispersion polymerization , copolymer , chemistry , nanotechnology , organic chemistry , magnetization , composite material , physics , quantum mechanics , magnetic field , engineering
A new method is applied to prepare stable aqueous dispersion of magnetic iron oxide nanoparticles (MNPs) by biocompatible maleate polymers. Fe 3 O 4 magnetic core–shell nanoparticles are obtained via forming an inclusion complex between carboxylic acid groups of maleated biocompatible polymers shell and Fe 3 O 4 MNPs core surface. Maleate polymers are synthesized via esterification of poly(ethylene glycol), poly(vinyl alcohol) and starch with maleic anhydride (MA). The Fe 3 O 4 magnetic core–shell nanoparticles are characterized by Fourier transform infrared spectroscopy, X‐ray diffraction, transmission electron microscopy and vibrating sample magnetometer. The obtained magnetic core–shell nanoparticles exhibit superparamagnetic property and reveal long‐term aqueous stability. This work represents a valid methodology to produce highly stable aqueous dispersion of Fe 3 O 4 MNPs ferrofluids which can be expected to have great potential as contrast agent for magnetic resonance imaging. Furthermore, the shell composition of biocompatible maleate polymers with double bond of MA as crosslinker agent allows the polymerization with other monomers to design preferred drug delivery systems. Copyright © 2014 John Wiley & Sons, Ltd.