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Spatial control of cell attachment using plasma micropatterned polymers
Author(s) -
Mitchell S. A.,
Emmison N.,
Shard A. G.
Publication year - 2002
Publication title -
surface and interface analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.52
H-Index - 90
eISSN - 1096-9918
pISSN - 0142-2421
DOI - 10.1002/sia.1444
Subject(s) - chinese hamster ovary cell , polystyrene , chemistry , hamster , polymer , masking (illustration) , plasma , resolution (logic) , cell , biophysics , chemical engineering , materials science , analytical chemistry (journal) , microbiology and biotechnology , chromatography , biochemistry , biology , organic chemistry , art , physics , receptor , quantum mechanics , artificial intelligence , computer science , engineering , visual arts
Surface chemical patterns of plasma‐polymerized hexane were produced using a simple masking technique. The rate of proliferation of Chinese hamster ovary (CHO) cells on the treated surfaces compared with untreated tissue culture polystyrene (TCPS) were found to correlate strongly with surface oxygen concentration. A topographical pattern resolution of better than 5 µm was achieved on a freshly cleaved mica surface. A similar chemical pattern resolution on TCPS was evidenced by the spatially selective attachment of CHO cells cultured in 10% serum. Copyright © 2002 John Wiley & Sons, Ltd.