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Distribution of body fluids, plasma protein, and sodium in dogs: A system dynamics model
Author(s) -
Hansen Jan E.,
Bie Peter
Publication year - 1987
Publication title -
system dynamics review
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.491
H-Index - 57
eISSN - 1099-1727
pISSN - 0883-7066
DOI - 10.1002/sdr.4260030204
Subject(s) - interstitial fluid , lymphatic system , plasma , interstitial space , distribution (mathematics) , chemistry , pathology , physics , medicine , mathematics , mathematical analysis , quantum mechanics
A whole‐body model of the microvascular and lymphatic transfer of fluid and plasma protein in dogs is presented. The model includes five compartments corresponding to well‐defined fluid spaces in the body: plasma, interstitial, lymphatic, erythrocyte, and cellular compartments. The transcapillary solute and solvent fluxes are computed from the Kedem‐Katchalsky and Patlak‐Bresler equations, respectively. A quantitative application of interstitial volume‐dependent exclusion of macromolecules is also included. Good agreement is found between simulated quantities and experimental data from conscious dogs in steady state and during two protocols of acute hypotonic overhydration. The model is a means of obtaining detailed quantitative descriptions of interactions between capillary and interstitial parameters that cannot be assessed experimentally.