Open AccessDonor‐defined mesenchymal stem cell antimicrobial potency against nontuberculous mycobacterium
Author(s) -
Bonfield Tracey L.,
Sutton Morgan T.,
Fletcher David R.,
Folz Michael A.,
Ragavapuram Vaishnavi,
Somoza Rodrigo A.,
Caplan Arnold I.
Publication year - 2021
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.1002/sctm.20-0521
Subject(s) - mesenchymal stem cell , nontuberculous mycobacteria , antimicrobial , mycobacterium fortuitum , potency , mycobacterium , stem cell , microbiology and biotechnology , biology , bacteria , in vitro , genetics
Chronic nontuberculous mycobacterial infections with Mycobacterium avium and Mycobacterium intracellulare complicate bronchiectasis, chronic obstructive airway disease, and the health of aging individuals. These insidious intracellular pathogens cause considerable morbidity and eventual mortality in individuals colonized with these bacteria. Current treatment regimens with antibiotic macrolides are both toxic and often inefficient at providing infection resolution. In this article, we demonstrate that human marrow‐derived mesenchymal stem cells are antimicrobial and anti‐inflammatory in vitro and in the context of an in vivo sustained infection of either M. avium and/or M. intracellulare .