Real‐time  in vivo  imaging collagen in lymphedematous skin using multiphoton microscopy | Zendy

Wu Xiufeng | Zendy; Zhuo Shuangmu | Zendy; Chen Jianxin | Zendy; Liu Ningfei | Zendy

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Real‐time in vivo imaging collagen in lymphedematous skin using multiphoton microscopy

Author(s) -

Wu Xiufeng,

Zhuo Shuangmu,

Chen Jianxin,

Liu Ningfei

Publication year - 2011

Publication title -

scanning

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.359

H-Index - 47

eISSN - 1932-8745

pISSN - 0161-0457

DOI - 10.1002/sca.20266

Subject(s) - in vivo , lymphedema , two photon excitation microscopy , biomedical engineering , multiphoton fluorescence microscope , pathology , microscopy , medicine , preclinical imaging , chemistry , fluorescence microscope , materials science , fluorescence , biology , optics , physics , microbiology and biotechnology , cancer , breast cancer

Changes of dermal collagen are characteristic for chronic lymphedema. To evaluate these changes, a real‐time imaging based on two‐photon excited fluorescence and second‐harmonic generation was developed for investigating collagen of lymphedematous mouse and rat tail skin in vivo . Our findings showed that the technique could image the morphological changes and distribution of collagen in lymphedematous mouse and rat tail skin in vivo . More importantly, it may allow visualization of dynamic collagen alteration during the progression of lymphedema. Our findings demonstrated that multiphoton microscopy may have potential in a clinical setting as an in vivo diagnostic and monitoring system for therapy in lymphology. SCANNING 33:463–467, 2011. © 2011 Wiley Periodicals, Inc.

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