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Genetic evolution of enterovirus 71: epidemiological and pathological implications
Author(s) -
Bible Jon M.,
Pantelidis Panagiotis,
Chan Paul K. S.,
Tong C. Y. William
Publication year - 2007
Publication title -
reviews in medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.06
H-Index - 90
eISSN - 1099-1654
pISSN - 1052-9276
DOI - 10.1002/rmv.538
Subject(s) - outbreak , epidemiology , enterovirus , enterovirus 71 , biology , pathological , genetic epidemiology , molecular epidemiology , serotype , evolutionary biology , virology , virus , genetics , medicine , genotype , pathology , gene
Since its discovery in the 1970s, enterovirus 71 (EV71) has become one of the most pathogenic enterovirus serotypes causing recurrent outbreaks in different parts of the world. Three waves of outbreaks globally have been recorded over the last three decades and more recently active circulation of EV71 is evident amongst countries in South East Asia and beyond. There is evidence of a continuous evolution in its genetic make up which is likely to impact on its epidemiology and pathological potential. This review examines the molecular genetics and evolution of EV71 in relation to its epidemiological and pathological properties. A thorough understanding of the relationship between the genetic changes and the resulting host–virus interaction is essential for successful control. Copyright © 2007 John Wiley & Sons, Ltd.