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Involvement of morbilliviruses in the pathogenesis of demyelinating disease
Author(s) -
Sips G. J.,
Chesik D.,
Glazenburg L.,
Wilschut J.,
De Keyser J.,
Wilczak N.
Publication year - 2007
Publication title -
reviews in medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.06
H-Index - 90
eISSN - 1099-1654
pISSN - 1052-9276
DOI - 10.1002/rmv.526
Subject(s) - morbillivirus , canine distemper , virology , paramyxoviridae , measles virus , biology , demyelinating disease , virus , multiple sclerosis , viral disease , immunology , measles , vaccination
Two members of the morbillivirus genus of the family Paramyxoviridae , canine distemper virus (CDV) and measles virus (MV), are well‐known for their ability to cause a chronic demyelinating disease of the CNS in their natural hosts, dogs and humans, respectively. Both viruses have been studied for their potential involvement in the neuropathogenesis of the human demyelinating disease multiple sclerosis (MS). Recently, three new members of the morbillivirus genus, phocine distemper virus (PDV), porpoise morbillivirus (PMV) and dolphin morbillivirus (DMV), have been discovered. These viruses have also been shown to induce multifocal demyelinating disease in infected animals. This review focuses on morbillivirus‐induced neuropathologies with emphasis on aetiopathogenesis of CNS demyelination. The possible involvement of a morbillivirus in the pathogenesis of multiple sclerosis is discussed. Copyright © 2007 John Wiley & Sons, Ltd.