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Death ligand‐mediated apoptosis in HIV infection
Author(s) -
Miura Yoshiharu,
Koyanagi Yoshio
Publication year - 2005
Publication title -
reviews in medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.06
H-Index - 90
eISSN - 1099-1654
pISSN - 1052-9276
DOI - 10.1002/rmv.462
Subject(s) - human immunodeficiency virus (hiv) , apoptosis , virology , programmed cell death , medicine , ligand (biochemistry) , immunology , biology , receptor , genetics
Apoptosis has been suggested to cause severe CD4 + T cell depletion in patients infected with HIV. This review focuses on the biological events involved in death ligand‐induced apoptosis during HIV infection. Among these ligands, TRAIL appears critical in HIV‐infection. Death ligand‐induced apoptosis might be a major pathogenic event in many virus‐induced diseases including AIDS and the clarification of its mechanism will aid in the development of therapeutic strategies. Copyright © 2005 John Wiley & Sons, Ltd.