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JC virus genotyping offers a new paradigm in the study of human populations
Author(s) -
Yogo Yoshiaki,
Sugimoto Chie,
Zheng HuaiYing,
Ikegaya Hiroshi,
Takasaka Tomokazu,
Kitamura Tadaichi
Publication year - 2004
Publication title -
reviews in medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.06
H-Index - 90
eISSN - 1099-1654
pISSN - 1052-9276
DOI - 10.1002/rmv.428
Subject(s) - genotyping , haplogroup , jc virus , genotype , biology , virology , phylogenetic tree , genetics , population , genetic variation , chromosome , archipelago , evolutionary biology , progressive multifocal leukoencephalopathy , virus , gene , demography , haplotype , ecology , sociology
A small DNA virus, named JC virus (JCV) and belonging to the Polyomaviridae , is attracting the attention of anthropologists worldwide, as JCV genotyping appears to be a novel means of elucidating human migrations and the origins of various ethnic groups. The basic properties of JCV, the regional distributions of JCV genotypes, and the phylogenetic relationships among various JCV genotypes are described. Then, a study is described in which the origin of the modern Japanese was extensively investigated using the JCV genotyping method. Based on JCV genotypes in neighboring areas, the origins of people who carried JCV genotypes to the Japanese Archipelago are discussed. Finally, the relationships between JCV genotypes and Y‐chromosome haplogroups are examined, as genetic variation on the Y chromosome has recently been examined in detail to investigate ancient human migrations and the population structures of human groups. Copyright © 2004 John Wiley & Sons, Ltd.