RNA interference: on the road to an alternate therapeutic strategy! | Zendy

Dave Rajnish S. | Zendy; Pomerantz Roger J. | Zendy

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RNA interference: on the road to an alternate therapeutic strategy!

Author(s) -

Dave Rajnish S.,

Pomerantz Roger J.

Publication year - 2003

Publication title -

reviews in medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.06

H-Index - 90

eISSN - 1099-1654

pISSN - 1052-9276

DOI - 10.1002/rmv.407

Subject(s) - rna interference , interference (communication) , computational biology , rna , computer science , medicine , biology , genetics , telecommunications , gene , channel (broadcasting)

RNA interference (RNAi) is a newly described natural biological phenomenon mediated by small interfering RNA (siRNA) molecules which target viral mRNA for degradation by cellular enzymes. RNAi has become a method of choice for studying gene function, especially in mammalian systems. With proof‐of‐concept studies already presented against a wide variety of human pathogens and several innovative methods of delivering the siRNA to a wide variety of primary cells available, the role for siRNA as a potential therapeutic strategy is becoming increasingly clear. This review presents recent advances in this direction. Copyright © 2003 John Wiley & Sons, Ltd.

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