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RNA interference: on the road to an alternate therapeutic strategy!
Author(s) -
Dave Rajnish S.,
Pomerantz Roger J.
Publication year - 2003
Publication title -
reviews in medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.06
H-Index - 90
eISSN - 1099-1654
pISSN - 1052-9276
DOI - 10.1002/rmv.407
Subject(s) - rna interference , interference (communication) , computational biology , rna , computer science , medicine , biology , genetics , telecommunications , gene , channel (broadcasting)
RNA interference (RNAi) is a newly described natural biological phenomenon mediated by small interfering RNA (siRNA) molecules which target viral mRNA for degradation by cellular enzymes. RNAi has become a method of choice for studying gene function, especially in mammalian systems. With proof‐of‐concept studies already presented against a wide variety of human pathogens and several innovative methods of delivering the siRNA to a wide variety of primary cells available, the role for siRNA as a potential therapeutic strategy is becoming increasingly clear. This review presents recent advances in this direction. Copyright © 2003 John Wiley & Sons, Ltd.