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HHV‐8 infection: a model for reactivation and transmission
Author(s) -
Corey Lawrence,
Brodie Scott,
Huang MeeiLi,
Koelle David M.,
Wald Anna
Publication year - 2002
Publication title -
reviews in medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.06
H-Index - 90
eISSN - 1099-1654
pISSN - 1052-9276
DOI - 10.1002/rmv.341
Subject(s) - virology , transmission (telecommunications) , human immunodeficiency virus (hiv) , biology , epidemiology , immunology , medicine , computer science , pathology , telecommunications
Abstract The rapid pace of knowledge about HHV‐8 since its discovery has been one of the most exciting aspects of medical virology in the last decade. As outlined in this review, the discovery by Drs Chang and Moore of this virus has opened up a broad field of biology with interesting contrasts between current epidemiological data for Kaposi's sarcoma and the cell biology of this gamma herpesvirus. In particular, we summarise the paucity of virological data supporting genital sites of replication and emphasise detection of HHV‐8 in the oropharynx. Hopefully continued study will address many of the critical questions that exist today regarding how this infection is transmitted and acquired. Copyright © 2001 John Wiley & Sons, Ltd.