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Cell death mechanisms involved in cell injury caused by SARS‐CoV‐2
Author(s) -
Morais da Silva Maríllya,
Lira de Lucena André Silva,
Paiva Júnior Sergio de Sá Leitão,
Florêncio De Carvalho Vanessa Mylenna,
Santana de Oliveira Priscilla Stela,
Rosa Michelle Melgarejo,
Barreto de Melo Rego Moacyr Jesus,
Pitta Maira Galdino da Rocha,
Pereira Michelly Cristiny
Publication year - 2022
Publication title -
reviews in medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.06
H-Index - 90
eISSN - 1099-1654
pISSN - 1052-9276
DOI - 10.1002/rmv.2292
Subject(s) - coronavirus , medicine , programmed cell death , immunology , disease , pneumonia , covid-19 , respiratory tract , lung , necrosis , apoptosis , respiratory system , severe acute respiratory syndrome , coronaviridae , virology , biology , pathology , infectious disease (medical specialty) , biochemistry
Coronavirus disease 2019 (Covid‐19) is an emerging novel respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) that rapidly spread worldwide. In addition to lung injury, Covid‐19 patients may develop extrapulmonary symptoms, including cardiac, liver, kidney, digestive tract, and neurological injuries. Angiotensin converting enzyme 2 is the major receptor for the entry of SARS‐CoV‐2 into host cells. The specific mechanisms that lead to cell death in different tissues during infection by SARS‐CoV‐2 remains unknown. Based on data of the previous human coronavirus SARS‐CoV together with information about SARS‐CoV‐2, this review provides a summary of the mechanisms involved in cell death, including apoptosis, autophagy, and necrosis, provoked by severe acute respiratory syndrome coronavirus.