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Innate immune evasion by SARS‐CoV ‐2: Comparison with SARS‐CoV
Author(s) -
Bouayad Abdellatif
Publication year - 2020
Publication title -
reviews in medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.06
H-Index - 90
eISSN - 1099-1654
pISSN - 1052-9276
DOI - 10.1002/rmv.2135
Subject(s) - cytokine storm , innate immune system , evasion (ethics) , immunology , immune system , inflammasome , coronaviridae , biology , virology , viral pathogenesis , virus , coronavirus , disease , covid-19 , medicine , infectious disease (medical specialty) , inflammation , viral replication , pathology
Summary SARS‐CoV‐2 virus, a member of the Coronaviridae family, causes Covid‐19 pandemic disease with severe respiratory illness. Multiple strategies enable SARS‐CoV‐2 to eventually overcome antiviral innate immune mechanisms which are important components of viral pathogenesis. This review considers several mechanisms of SARS‐CoV‐2 innate immune evasion including suppression of IFN‐α/β production at the earliest stage of infection, mechanisms that exhaust natural killer cell‐mediated cytotoxicity, overstimulation of NLRP3 inflammasome and induction of a cytokine storm. A comparison with SARS‐CoV is made. Greater knowledge of these and other immune evasion tactics may provide us with improved possibilities for research into this novel deadly virus.