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Long noncoding RNAs: Novel regulators of virus‐host interactions
Author(s) -
Liu Shaoqiong,
Liu Xia,
Li Juan,
Zhou Hong,
Carr Michael J.,
Zhang Zhenjie,
Shi Weifeng
Publication year - 2019
Publication title -
reviews in medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.06
H-Index - 90
eISSN - 1099-1654
pISSN - 1052-9276
DOI - 10.1002/rmv.2046
Subject(s) - biology , epigenetics , innate immune system , viral pathogenesis , host (biology) , computational biology , immune system , microrna , host factors , regulation of gene expression , virus , gene , immunology , genetics , viral replication
Summary Long noncoding RNAs (lncRNAs) represent a key class of cellular regulators, involved in the modulation and control of multiple biological processes. Distinct classes of lncRNAs are now known to be induced by host cytokines following viral infections. Current evidence demonstrates that lncRNAs play essential roles at the host‐pathogen interface regulating viral infections by either innate immune responses at various levels including activation of pathogen recognition receptors or by epigenetic, transcriptional, and posttranscriptional effects. We review the newly described mechanisms underlying the interactions between lncRNAs, cytokines, and metabolites differentially expressed following viral infections; we highlight the regulatory networks of host antiviral responses and emphasize the need for interdisciplinary research between lncRNA biology and immunology to deepen understanding of viral pathogenesis.