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BK virus: Current understanding of pathogenicity and clinical disease in transplantation
Author(s) -
Chong Stephanie,
Antoni Michelle,
Macdonald Andrew,
Reeves Matthew,
Harber Mark,
Magee Ciara N.
Publication year - 2019
Publication title -
reviews in medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.06
H-Index - 90
eISSN - 1099-1654
pISSN - 1052-9276
DOI - 10.1002/rmv.2044
Subject(s) - disease , medicine , epidemiology , pathogenicity , transplantation , bk virus , intensive care medicine , immunology , virus , virology , transmission (telecommunications) , kidney transplantation , biology , electrical engineering , microbiology and biotechnology , engineering
Summary BK polyomavirus (BKV) is an important cause of graft loss in renal transplant recipients that continues to pose a significant challenge to clinicians due to its frequently unpredictable onset, persistence, and the lack of effective antiviral agents or prevention strategies. This review covers our current understanding of epidemiology, viral transmission and disease progression, and treatment and prevention strategies that have been used to manage this disease.