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Developmental progress of CRISPR/Cas9 and its therapeutic applications for HIV‐1 infection
Author(s) -
Deng Qiudi,
Chen Zisheng,
Shi Lei,
Lin Huafeng
Publication year - 2018
Publication title -
reviews in medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.06
H-Index - 90
eISSN - 1099-1654
pISSN - 1052-9276
DOI - 10.1002/rmv.1998
Subject(s) - crispr , cas9 , genome editing , human immunodeficiency virus (hiv) , computational biology , biology , computer science , medicine , gene , virology , genetics
Summary The CRISPR/Cas9 system has been developed as a powerful tool for targeted gene editing. As a result of technical enhancements in recent years, this technology has become the method of choice for efficiently modifying targeted HIV‐1 genome efficiently as part of HIV therapy. CRISPR can be modified to target specific sequences that Cas9 then cuts. In this article, we outline the development of the CRISPR/Cas9 system. We also show how this technology can be used for the prevention and treatment of HIV‐1 infection. Optimistically, this technology promises to make a significant impact on the fight against HIV‐1 in the future.