Premium
The neurological complications of chikungunya virus: A systematic review
Author(s) -
Mehta Ravi,
Gerardin Patrick,
Brito Carlos Alexandre Antunes,
Soares Cristiane Nascimento,
Ferreira Maria Lucia Brito,
Solomon Tom
Publication year - 2018
Publication title -
reviews in medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.06
H-Index - 90
eISSN - 1099-1654
pISSN - 1052-9276
DOI - 10.1002/rmv.1978
Subject(s) - chikungunya , systematic review , medicine , disease , intensive care medicine , virus , public health , chikungunya fever , scopus , medline , virology , biology , pathology , biochemistry
Summary We performed a systematic review on the neurological complications of chikungunya virus. Such complications are being reported increasingly, owing primarily to the scale of recent epidemics but also to a growing understanding of the virus' neurovirulence. We performed a thorough literature search using PubMed and Scopus databases, summating the data on all published reports of neurological disease associated with chikungunya virus. We appraised the data for each major condition in adults, children, and neonates, as well as evaluating the latest evidence on disease pathogenesis and management strategies. The review provides a comprehensive summary for clinicians, public health officials, and researchers tackling the challenges associated with this important emerging pathogen.