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Immunity against hepatitis E virus infection: Implications for therapy and vaccine development
Author(s) -
Hakim Mohamad S.,
Ikram Aqsa,
Zhou Jianhua,
Wang Wenshi,
Peppelenbosch Maikel P.,
Pan Qiuwei
Publication year - 2018
Publication title -
reviews in medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.06
H-Index - 90
eISSN - 1099-1654
pISSN - 1052-9276
DOI - 10.1002/rmv.1964
Subject(s) - hepatitis e virus , immunology , immunity , immune system , medicine , virology , acquired immune system , virus , vaccination , viral hepatitis , biology , genotype , biochemistry , gene
Summary Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide and an emerging cause of chronic infection in immunocompromised patients. As with viral infections in general, immune responses are critical to determine the outcome of HEV infection. Accumulating studies in cell culture, animal models and patients have improved our understanding of HEV immunopathogenesis and informed the development of new antiviral therapies and effective vaccines. In this review, we discuss the recent progress on innate and adaptive immunity in HEV infection, and the implications for the devolopment of effective vaccines and immune‐based therapies.