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Human pegivirus (HPgV) infection in sub‐Saharan Africa—A call for a renewed research agenda
Author(s) -
Singh Shivank,
Blackard Jason T.
Publication year - 2017
Publication title -
reviews in medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.06
H-Index - 90
eISSN - 1099-1654
pISSN - 1052-9276
DOI - 10.1002/rmv.1951
Subject(s) - gb virus c , human immunodeficiency virus (hiv) , virology , biology , environmental health , medicine , flaviviridae , viral disease
Summary The human pegivirus (HPgV)—formerly GB virus C—has a beneficial impact on HIV disease progression that has been described in multiple studies. Given the high prevalence of HIV in sub‐Saharan Africa and the continuing need to suppress HIV replication, this review provides a comprehensive overview of the existing data on HPgV infection in sub‐Saharan Africa, with a particular focus on studies of prevalence and the circulating HPgV genotypes. This review also highlights the need for additional studies of HPgV conducted on the African continent and proposes a research agenda for evaluation of HPgV.