Premium
Fc gamma receptors in respiratory syncytial virus infections: implications for innate immunity
Author(s) -
Jans Jop,
Vissers Marloes,
Heldens Jacco G.M.,
Jonge Marien I.,
Levy Ofer,
Ferwerda Gerben
Publication year - 2014
Publication title -
reviews in medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.06
H-Index - 90
eISSN - 1099-1654
pISSN - 1052-9276
DOI - 10.1002/rmv.1773
Subject(s) - immunity , innate immune system , immunology , antibody , immune system , vaccination , virus , receptor , virology , biology , passive immunity , medicine , biochemistry
SUMMARY RSV infections are a major burden in infants less than 3 months of age. Newborns and infants express a distinct immune system that is largely dependent on innate immunity and passive immunity from maternal antibodies. Antibodies can regulate immune responses against viruses through interaction with Fc gamma receptors leading to enhancement or neutralization of viral infections. The mechanisms underlying the immunomodulatory effect of Fc gamma receptors on viral infections have yet to be elucidated in infants. Herein, we will discuss current knowledge of the effects of antibodies and Fc gamma receptors on infant innate immunity to RSV. A better understanding of the pathogenesis of RSV infections in young infants may provide insight into novel therapeutic strategies such as vaccination. Copyright © 2013 John Wiley & Sons, Ltd.