Open AccessOvarian tissue grafting: Lessons learnt from our experience with 55 grafts
Author(s) -
Rozen Genia,
Sii Stephanie,
Agresta Franca,
Gook Debra,
Polyakov Alex,
Stern Catharyn
Publication year - 2021
Publication title -
reproductive medicine and biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.005
H-Index - 22
eISSN - 1447-0578
pISSN - 1445-5781
DOI - 10.1002/rmb2.12380
Subject(s) - cryopreservation , follicular phase , medicine , ovarian tissue cryopreservation , retrospective cohort study , fertility preservation , ovarian tissue , pregnancy , andrology , ovary , gynecology , physiology , surgery , biology , fertility , embryo , population , genetics , environmental health , microbiology and biotechnology
Purpose Uncertainties remain regarding the clinical efficacy of ovarian tissue cryopreservation and grafting. We report a retrospective analysis of reproductive outcomes and lessons learnt following 55 ovarian tissue transplant procedures at our center from 2006 to 2019. Methods We analyzed variables related to graft success such as tissue volume, follicular density, total follicular volume, and age on the duration of graft function. Results Follicular density and total follicular volume correlate positively with duration of graft function. All clinical pregnancies in our cohort occurred in women who were aged 35 or less at the time of ovarian tissue cryopreservation. Conclusion Graft success, as determined by eventual pregnancy and the longevity of graft function, may be impacted by factors including age at cryopreservation, follicular density, and total follicular volume.