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Development and in vivo assessment of a novel MRI‐compatible headframe system for the ovine animal model
Author(s) -
Trovatelli Marco,
Brizzola Stefano,
Zani Davide Danilo,
Castellano Antonella,
Mangili Paola,
Riva Marco,
Woolley Max,
Johnson Dave,
Rodriguez y Baena Ferdinando,
Bello Lorenzo,
Falini Andrea,
Secoli Riccardo
Publication year - 2021
Publication title -
the international journal of medical robotics and computer assisted surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.556
H-Index - 53
eISSN - 1478-596X
pISSN - 1478-5951
DOI - 10.1002/rcs.2257
Subject(s) - ex vivo , in vivo , computer science , animal model , neurosurgery , medicine , biomedical engineering , nuclear medicine , medical physics , radiology , biology , microbiology and biotechnology
Abstract Background The brain of sheep has primarily been used in neuroscience as an animal model because of its similarity to the human brain, in particular if compared to other models such as the lissencephalic rodent brain. Their brain size also makes sheep an ideal model for the development of neurosurgical techniques using conventional clinical CT/MRI scanners and stereotactic systems for neurosurgery. Methods In this study, we present the design and validation of a new CT/MRI compatible head frame for the ovine model and software, with its assessment under two real clinical scenarios. Results Ex‐vivo and in vivo trial results report an average linear displacement of the ovine head frame during conventional surgical procedures of 0.81 mm for ex‐vivo trials and 0.68 mm for in vivo tests, respectively. Conclusions These trial results demonstrate the robustness of the head frame system and its suitability to be employed within a real clinical setting.