Open AccessMultiple cerebral infarctions in ROS1 ‐rearranged lung adenocarcinoma
Author(s) -
Ikushima Hiroaki,
Hiraishi Yoshihisa,
Toriumi Kanto,
Ando Takahiro,
Tamiya Hiroyuki,
Ishida Junichi,
Amano Yosuke,
Kage Hidenori,
Tanaka Goh,
Nagase Takahide
Publication year - 2021
Publication title -
respirology case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 9
ISSN - 2051-3380
DOI - 10.1002/rcr2.831
Subject(s) - medicine , adenocarcinoma , lung , thrombosis , cohort , oncology , adenocarcinoma of the lung , ros1 , targeted therapy , cerebral infarction , lung cancer , radiology , gastroenterology , pathology , cardiology , cancer , ischemia
Rearrangements of specific tyrosine kinases are associated with an elevated risk of venous thrombosis in lung adenocarcinoma, although their effects on arterial thrombosis have not been fully elucidated. Here, we report two cases of ROS proto‐oncogene 1 ( ROS1 )‐rearranged lung adenocarcinoma with cerebral infarction during the peri‐diagnostic period. Two cases took contrasting clinical courses: one patient could not receive targeted therapy because of a significant decline in performance status, whereas in the other patient, the performance status was maintained and targeted therapy drastically reduced the tumour size. Our cases suggest close monitoring could be considered in the selected cohort.