Open AccessHyper‐progressive disease after immune checkpoint inhibitor in SMARCA4 ‐deficient small‐cell lung carcinoma
Author(s) -
Chiba Yosuke,
Kawanami Toshinori,
Yamasaki Kei,
Uchimura Keigo,
Matsuyama Atsuji,
Yatera Kazuhiro
Publication year - 2020
Publication title -
respirology case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 9
ISSN - 2051-3380
DOI - 10.1002/rcr2.667
Subject(s) - medicine , nivolumab , small cell lung carcinoma , pleural effusion , progressive disease , lung , lung cancer , oncology , chemotherapy , cancer research , immunotherapy , small cell carcinoma , cancer
SMARCA4 (switch/sucrose non‐fermentable‐related, matrix‐associated, actin‐dependent regulator of chromatin, subfamily A, member 4)‐deficient thoracic tumours have shown poor prognosis in clinical settings. Although the optimal treatment for SMARCA4‐deficient thoracic tumours remains unclear, existing studies indicate a favourable response of these tumours to immune checkpoint inhibitors (ICIs). However, there are no reports of fatality in SMARCA4‐deficient small‐cell lung carcinoma (SCLC) with hyper‐progressive disease (HPD) upon treatment with ICIs. Herein, we report a patient with SMARCA4‐deficient SCLC who had HPD after the first ICI treatment. A 35‐year‐old man was treated with nivolumab, subsequent to cytotoxic chemotherapy. A week after nivolumab initiation, chest computed tomography revealed marked increase in pleural effusion in the right lung and chest wall dissemination of the tumour, which concur with the definition of HPD. This is the first study to report the occurrence of HPD after treatment with ICIs in a patient with SMARCA4‐deficient SCLC. Analysis of additional data is necessary to determine the optimal treatment for these patients.