Open AccessSMARCA4 ‐deficient lung tumour that presented with haemoptysis and progressed rapidly
Author(s) -
Inoue Mari,
Enomoto Tatsuji,
Kawamoto Masashi,
Mikami Naoto,
Kuribayashi Hidehiko,
Saeki Noriyuki
Publication year - 2020
Publication title -
respirology case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 9
ISSN - 2051-3380
DOI - 10.1002/rcr2.656
Subject(s) - immunohistochemistry , pathological , medicine , smarca4 , pathology , lung , eosinophilic , biology , gene expression , biochemistry , chromatin remodeling , gene
The case of a heavy ex‐smoking man in his early 70s who presented with haemoptysis and died following rapid progression is presented. The tumour excised by surgery was mostly composed of monotonous large rhabdoid cells showing prominent nucleoli and eosinophilic cytoplasm. On immunohistochemistry with SMARCA4 (BRG‐1), the tumour cells showed significant loss of expression. The tumour was diagnosed as a SMARCA4‐deficient thoracic sarcoma. This is a disease that progresses rapidly and has a poor prognosis. However, the search for specific treatments using synthetic lethality is underway. Clinical and pathological characteristics can be identified with examination of more cases, and when the tumour is suspected, it is necessary to actively perform immunohistochemical examination.