Open AccessInvasive tracheal aspergillosis after chemoradiotherapy treatment
Author(s) -
Lee Shok Yin,
Nguyen Phan,
Chapman Sally
Publication year - 2019
Publication title -
respirology case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 9
ISSN - 2051-3380
DOI - 10.1002/rcr2.473
Subject(s) - medicine , voriconazole , chemoradiotherapy , context (archaeology) , aspergillus fumigatus , aspergillosis , positron emission tomography , radiology , biopsy , rare disease , computed tomography , lung cancer , pathology , antifungal , radiation therapy , disease , dermatology , paleontology , biology , immunology
Invasive tracheobronchial aspergillosis is a rare disease with most reported cases in the literature occurring in immunocompromised hosts. We report an unusual case of a patient with persistent cough and dyspnoea in the context of prior chemoradiotherapy for primary lung cancer. Chest computed tomography (CT) demonstrated an abnormal soft tissue mass surrounding the trachea and carina, with focal moderate fluorodeoxyglucose (FDG) activity on positron emission tomography (PET) scan. Bronchoscopic biopsy revealed fungal hyphae associated with necrosis and cartilage invasion, subsequently confirmed to be Aspergillus fumigatus complex. The patient was commenced on antifungal therapy promptly and had a good clinical response to treatment.