Open AccessA case of secondary pulmonary alveolar proteinosis, but prior to myelodysplastic syndrome
Author(s) -
Zhao Yunfeng,
Xiong Wei,
Wu Xueling
Publication year - 2013
Publication title -
respirology case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 9
ISSN - 2051-3380
DOI - 10.1002/rcr2.29
Subject(s) - medicine , pulmonary alveolar proteinosis , eosinophilic , pathology , bone marrow , bone marrow examination , lung , gastroenterology
Pulmonary alveolar proteinosis ( PAP ) is a rare lung disorder. We herein report the first case of PAP that happened 2 years before myelodysplatic syndrome ( MDS ). A 34‐year‐old C hinese presented with a developed recurrent cough and shortness of breath. Computed tomography scan disclosed ground‐glass opacities with interlobular septal thickening. Histological examination showed eosinophilic dense homogenous material filling in the alveolar. This precipitate had a fine granular appearance. The eosinophilic material was periodic acid– S chiff reaction‐positive. The patient was diagnosed with PAP . Two years later he was admitted to a hospital because of dizziness of 1‐month duration. Hematological examination showed white blood cells was 2700, hemoglobin was 7.4 g/ dL , and platelet count was 21,000 platelets/mm 3 . Following bone marrow biopsy and histopathologic examination, he was diagnosed with MDS with refractory anemia and excess blasts. So for PAP patients, follow‐up tests should be considered in order to find any possible underlying disease.