Open AccessAcute onset of ulcerative colitis during chemoradiotherapy for anaplastic lymphoma kinase‐positive lung adenocarcinoma
Author(s) -
Fujita Kohei,
Mizumoto Yoshinori,
Moriyoshi Koki,
Araki Norio,
Mio Tadashi
Publication year - 2018
Publication title -
respirology case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 9
ISSN - 2051-3380
DOI - 10.1002/rcr2.288
Subject(s) - medicine , pancolitis , vinorelbine , mesalazine , colonoscopy , adenocarcinoma , ulcerative colitis , gastroenterology , anaplastic lymphoma kinase , chemoradiotherapy , oxaliplatin , colitis , chemotherapy , oncology , lung cancer , colorectal cancer , cancer , cisplatin , disease , malignant pleural effusion
We report a case of acute onset of ulcerative colitis (UC) during chemoradiotherapy in a patient with anaplastic lymphoma kinase (ALK)‐positive lung adenocarcinoma. A 46‐year‐old male patient with an abnormal chest shadow was referred to our hospital. He was diagnosed with lung adenocarcinoma, clinical stage T1aN3M0 and stage IIIB. Concurrent chemoradiotherapy was selected for his initial therapy. After two cycles of cisplatin and vinorelbine administration, he experienced persistent diarrhoea and anorexia. Findings of the colonoscopy revealed a pancolitis type of UC. After discontinuation of chemotherapy, oral administration of mesalazine was initiated. The development of UC during chemotherapy is very rare and only a few case reports have been published. Although adverse events are rare, it is very important to assess the colitis precisely by performing a colonoscopy when protracted abdominal pain is experienced by the patient, along with diarrhoea or bloody stool during chemotherapy.