Open AccessDiffuse idiopathic pulmonary neuroendocrine cell hyperplasia diagnosed by tranbronchoscopic cryoprobe biopsy technique
Author(s) -
Patel Ravi,
CollazoGonzalez Carolina,
Andrews Arthur,
Johnson Jean,
Rumbak Mark,
Smith Maxwell
Publication year - 2017
Publication title -
respirology case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.304
H-Index - 9
ISSN - 2051-3380
DOI - 10.1002/rcr2.275
Subject(s) - medicine , pulmonary function testing , biopsy , lung , radiology , chronic cough , obstructive lung disease , lung biopsy , air trapping , hyperplasia , neuroendocrine cell , asthma , pulmonary disease , exertional dyspnea , pathology , presentation (obstetrics) , immunohistochemistry
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) remains a poorly understood clinical entity. It is currently classified as a premalignant condition by the World Health Organization (WHO). Symptoms are similar to those associated with obstructive lung disease, including breathlessness and cough. The presentation is often initially ascribed to other diseases such as asthma or chronic obstructive pulmonary disease. Here, we present what we believe is the first described case of DIPNECH diagnosed by transbronchoscopic cryoprobe biopsy. The patient presented with chronic cough, dyspnoea, pulmonary function tests consistent with obstruction, and a computed tomography (CT) scan of chest with multiple nodules. The patient went on to have transbronchoscopic cryoprobe biopsies of the lung, which confirmed the diagnosis of DIPNECH.